Brain tissue boosted after six-week treatment for chronic suicidality | PG电子游戏官站 | University of the Sunshine Coast, 昆士兰, 澳大利亚

可访问性链接

Brain tissue boosted after six-week treatment for chronic suicidality

2021年11月2

Neuroscience researchers from PG电子平台 澳大利亚 have found a link between low-dose ketamine treatment and increased grey matter volume in areas of the brain associated with depression and suicidality.

The study, from PG电子平台’s 汤普森研究所, was published in Psychiatry 研究: Neuroimaging, with the team behind it now looking to conduct a similar study for post-traumatic stress disorder.

Lead authors Cyrana Gallay and Grace Forsyth said that after a six-week treatment of low-dose ketamine, areas of the brain associated with depression and suicidality showed improvement.

“In people suffering from depression, we expect to see atrophied brain tissue in certain regions, meaning that brain cells may be shrunken, shut down or not communicating properly,加莱女士说.

“After six weeks of low-dose ketamine treatment, we found increased grey matter volume in key brain areas associated with suicidality and depression; effectively mirroring what a healthier brain would look like.”

The team clinically administered oral ketamine in micro-doses ranging from 0.05 to 3.0 mg/kg, which is far below the dosing commonly used in medical anaesthesia.

Ms Forsyth said previous studies had shown low-dose ketamine promoted cell function and increased cell branches and communication pathways within a matter of days.

“Low-dose ketamine activates the glutamatergic system, 一个重要的, naturally occurring chemical in the brain responsible for the promotion of learning and memory, among other key brain functions,福赛斯说.

The findings follow an earlier published paper by the same author group in 转化精神病学, which found that 69 percent of participants reported clinically significant reduction in suicide ideation.

Director of the 汤普森研究所 and senior researcher on the study, Professor Jim Lagopoulos, said an increasing number of similar studies were showing positive impacts from low-dose psychedelic treatments.

“Psychedelics delivered in a clinical setting are a growing field of interest and there is enormous potential for developing treatments that are accessible, sustainable and potentially more effective than the treatments we have now,” Professor Lagopoulos said.

“Ketamine is used as a medical anaesthetic, particularly for children because it is so safe and well-tolerated. It has an incredible history of helping burns victims and veterans recovering from surgery and was discovered almost by mistake for use in mental health after medical patients began reporting better moods after their treatment.”

“However, during the post-war era, misuse and social stigma eroded the public perception of ketamine. But despite concern that it can be addictive, in a clinical setting we find that people tend to be able to go longer periods of time between low-dose ketamine treatments.”

Professor Lagopoulos said there was a pressing need to consider new and alternative treatments for mental health conditions.

“The mental health system is facing unprecedented demand, so we need to look past the treatments that really haven’t been updated for a long time and consider new options that have a growing body of scientific evidence that suggests they are safe and effective,”他说.

People looking to sign up to a similar study for PTSD can visit www.南加州大学.edu.au/thompson-institute/research/post-traumatic-stress-disorder.

相关文章

Spider venom could be key to stopping devastating honeybee mite
7月4

A University of the Sunshine Coast researcher is investigating whether spider and scorpion venoms have the potential to save 澳大利亚’s honeybees from the invasive and deadly varroa mite parasite.

Spider venom could be key to stopping devastating honeybee mite
7月4

A University of the Sunshine Coast researcher is investigating whether spider and scorpion venoms have the potential to save 澳大利亚’s honeybees from the invasive and deadly varroa mite parasite.

Fireworks in the sky, chaos in the mind
6月29日

Percy would have felt rattled every time a firework erupted in the sky above.

PG电子游戏官站人:media@南加州大学.edu.au

的名字 位置 电子邮件 电话
詹妮尔柯克兰 媒体经理(代理) jkirklan@南加州大学.edu.au +61 7 5459 4553
克莱尔麦凯 Media Relations Coordinator cmckay@南加州大学.edu.au +61 7 5456 5669

找一个专家

With local and global expertise, PG电子平台 academics can assist journalists on a variety of topics.

的搜索结果 最近 新闻